{"id":1798,"date":"2025-09-29T08:56:32","date_gmt":"2025-09-29T08:56:32","guid":{"rendered":"https:\/\/zembrin-shop.com\/?p=1798"},"modified":"2025-09-29T09:03:20","modified_gmt":"2025-09-29T09:03:20","slug":"proof-of-concept-randomisierte","status":"publish","type":"post","link":"https:\/\/zembrin-shop.com\/en\/proof-of-concept-randomisierte\/","title":{"rendered":"Proof-of-Concept randomisierte"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1798\" class=\"elementor elementor-1798\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a22f921 e-flex e-con-boxed e-con e-parent\" data-id=\"a22f921\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-96d824a e-con-full e-flex e-con e-child\" data-id=\"96d824a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d4543fc elementor-widget elementor-widget-image\" data-id=\"d4543fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"394\" height=\"317\" src=\"https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Proof-of-Concept-randomisierte.png\" class=\"attachment-full size-full wp-image-1800\" alt=\"\" srcset=\"https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Proof-of-Concept-randomisierte.png 394w, https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Proof-of-Concept-randomisierte-300x241.png 300w\" sizes=\"(max-width: 394px) 100vw, 394px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b3c79fe e-con-full e-flex e-con e-child\" data-id=\"b3c79fe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c93be75 elementor-widget elementor-widget-heading\" data-id=\"c93be75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Proof-of-Concept randomisierte<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30f9149 elementor-widget elementor-widget-text-editor\" data-id=\"30f9149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Proof-of-Concept randomisierte, kontrollierte Studie zu kognitiven Effekten des propriet\u00e4ren Extrakts Sceletium tortuosum (Zembrin), der auf Phosphodiesterase-4 bei kognitiv gesunden Probanden abzielt: Implikationen f\u00fcr die Alzheimer-Demenz<\/p><p>Chiu, Simon &amp; Gericke, Nigel &amp; Woodbury, Michel &amp; Badmaev, Vladimir &amp; Raheb, Hana &amp; Terpstra, Kristen &amp; Antongiorgi, Joalex &amp; Bureau, Yves &amp; Cernovsky, Zack &amp; Hou, Jirui &amp; Sanchez, Veronica &amp; Williams, Marissa &amp; Copen, John &amp; Husni, Mariwan &amp; Goble, Liz<\/p><p>(2014) EVIDENZBASIERTE KOMPLEMENT\u00c4R- UND ALTERNATIVMEDIZIN : ECAM. 2014. 682014. 10.1155\/2014\/682014.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e2edc4 e-flex e-con-boxed e-con e-parent\" data-id=\"4e2edc4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8d57e13 elementor-widget elementor-widget-heading\" data-id=\"8d57e13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"\/en\/kognitiver-support\/\">Kurzfassung:<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-502e532 elementor-widget elementor-widget-text-editor\" data-id=\"502e532\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00dcbereinstimmende Beweise deuten darauf hin, dass PDE-4 (Phosphodiesterase Subtyp 4) eine entscheidende Rolle bei der Regulierung der Kognition spielt \u00fcber die PDE-4-cAMP-Kaskaden-Signalisierung mit phosphoryliertem cAMP-Response-Element-Bindungsprotein (CREB). Ziel: der Prim\u00e4rer Endpunkt war die Untersuchung der neurokognitiven Wirkungen des Extraktes Sceletium tortuosum (Zembrin) und die Beurteilung der Sicherheit und<\/p><p>Vertr\u00e4glichkeit von Zembrin bei kognitiv gesunden Kontrollpersonen. Methode. Wir w\u00e4hlten die randomisierte doppelblinde, plazebokontrollierte Cross-Over-Design in unserer Studie. Wir randomisierten normale gesunde Probanden (insgesamt \ud835\udc5b = 21), die entweder eine 25mg-Kapsel Zembrin oder Placebo-Kapsel einmal t\u00e4glich \u00fcber 3 Wochen in einem randomisierten, placebokontrollierten 3-Wochen-Cross-over-Design. Von neuropsychologischen Tests: ZNS-Vitalzeichen und Hamilton-Depressions-Ratingskala (HAM-D) zu Beginn und in regelm\u00e4\u00dfigen Abst\u00e4nden und \u00fcberwachte Nebenwirkungen mit der Skala der bei der Behandlung auftretenden unerw\u00fcnschten Ereignisse. Ergebnisse. 21 Probanden (mittleres Alter: 54,6 Jahre \u00b1 6,0 Jahre; M\u00e4nner\/Frauen-Verh\u00e4ltnis: 9\/12) nahmen an der Studie teil. Zembrin bei einer Tagesdosis von 25 mg verbesserte im Vergleich zur Placebogruppe signifikant die kognitive Set-Flexibilit\u00e4t (\ud835\udc43 &lt; 0,032) und die exekutive Funktion (\ud835\udc43 &lt; 0,022). Es wurden positive Ver\u00e4nderungen in der Stimmung und im Schlaf festgestellt. Zembrin wurde gut toleriert. Schlussfolgerung. Die vielversprechenden kognitiv verst\u00e4rkenden Effekte von Zembrin implizieren wahrscheinlich die PDE-4-cAMP-CREB<\/p><p>Cascade, ein neuartiges Angriffsziel f\u00fcr Medikamente zur m\u00f6glichen Behandlung der fr\u00fchen Alzheimer-Demenz. Diese Studie ist bei ClinicalTrials.gov registriert NCT01805518.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Proof-of-Concept randomized controlled study of cognitive effects of a proprietary extract Sceletium tortuosum (Zembrin) &#8230;<\/p>","protected":false},"author":2,"featured_media":1800,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Proof-of-Concept randomisierte - Zembrin<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zembrin-shop.com\/en\/proof-of-concept-randomisierte\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Proof-of-Concept randomisierte - 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