{"id":739,"date":"2025-09-24T08:18:56","date_gmt":"2025-09-24T08:18:56","guid":{"rendered":"https:\/\/zembrin-shop.com\/?p=739"},"modified":"2025-09-29T08:44:37","modified_gmt":"2025-09-29T08:44:37","slug":"akute-wirkungen-von-sceletium-tortuosum-zembrin","status":"publish","type":"post","link":"https:\/\/zembrin-shop.com\/en\/akute-wirkungen-von-sceletium-tortuosum-zembrin\/","title":{"rendered":"Akute Wirkungen von Sceletium tortuosum (Zembrin)"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"739\" class=\"elementor elementor-739\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8530f90 e-flex e-con-boxed e-con e-parent\" data-id=\"8530f90\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-65a04bd e-con-full e-flex e-con e-child\" data-id=\"65a04bd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c63daf elementor-widget elementor-widget-image\" data-id=\"9c63daf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"400\" height=\"319\" src=\"https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Akute-Wirkungen-von-Sceletium-tortuosum-Zembrin.webp\" class=\"attachment-full size-full wp-image-1730\" alt=\"\" srcset=\"https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Akute-Wirkungen-von-Sceletium-tortuosum-Zembrin.webp 400w, https:\/\/zembrin-shop.com\/wp-content\/uploads\/2025\/09\/Akute-Wirkungen-von-Sceletium-tortuosum-Zembrin-300x239.webp 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ac195ee e-con-full e-flex e-con e-child\" data-id=\"ac195ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c04466a elementor-widget elementor-widget-heading\" data-id=\"c04466a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Akute Wirkungen von Sceletium tortuosum (Zembrin)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-40a4cc0 elementor-widget elementor-widget-text-editor\" data-id=\"40a4cc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Akute Wirkungen von Sceletium tortuosum (Zembrin), einem dualen 5-HT-Wiederaufnahme- und PDE4-Hemmer, in der menschlichen Amygdala und seine Verbindung zum Hypothalamus<\/p><p>Terburg, David &amp; Syal, Supriya &amp; Rosenberger, Lisa &amp; Heany, Sarah &amp; Phillips, Nicole &amp; Gericke, Nigel &amp; Stein, Dan &amp; van Honk, Jack<\/p><p>(2013) NEUROPSYCHOPHARMAKOLOGIE : OFFIZIELLE VER\u00d6FFENTLICHUNG DES AMERIKANISCHEN COLLEGES F\u00dcR NEUROPSYCHOPHARMAKOLOGIE. 38. 10.1038\/npp.2013.183.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1a156f6 e-flex e-con-boxed e-con e-parent\" data-id=\"1a156f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dc271e6 elementor-widget elementor-widget-heading\" data-id=\"dc271e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"\/en\/kognitiver-support\/\">Kurzfassung:<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4a71c7 elementor-widget elementor-widget-text-editor\" data-id=\"a4a71c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Die s\u00fcdafrikanische endemische Pflanze Sceletium tortuosum wird seit langem traditionell von den San und Khoikhoi und sp\u00e4ter von den europ\u00e4ischen Kolonialbauern als psychotropes Mittel in Tinkturform als Kau- und Heilmittel verwendet. In den letzten zehn Jahren hat die Pflanze zunehmend Aufmerksamkeit f\u00fcr ihre m\u00f6glichen Anwendungen zur F\u00f6rderung des Wohlbefindens und zur Linderung von Stress bei gesunden Menschen sowie zur Behandlung von klinischer Angst und Depression erregt. Die pharmakologischen Wirkungen eines standardisierten Extrakts der Pflanze (Zembrin) sind Berichten zufolge die duale PDE4-Hemmung und die 5-HT-Wiederaufnahmehemmung, eine Kombination, die angeblich potenzielle therapeutische Vorteile bietet. Hier testeten wir die akuten Wirkungen der Zembrin-Verabreichung in einer Pharmaco-fMRI-Studie, die sich auf die angstbezogene Aktivit\u00e4t in der Amygdala und den damit verbundenen Neurokreisl\u00e4ufen konzentrierte. In einem doppelblinden, plazebo-kontrollierten Cross-Over-Design wurden 16 gesunde Teilnehmer w\u00e4hrend der Leistung in einer Wahrnehmungsbelastung und einer emotionsm\u00e4ssig passenden Aufgabe gescannt. Die Reaktivit\u00e4t der Amygdala auf \u00e4ngstliche Gesichter unter Bedingungen niedriger Wahrnehmungsbelastung war nach einer einzigen 25-mg-Dosis Zembrin abgeschw\u00e4cht. Die anschlie\u00dfende Konnektivit\u00e4tsanalyse der Emotionsmatching-Aufgabe zeigte, dass die Amygdala-Hypothalamus-Kopplung ebenfalls reduziert war. Diese Ergebnisse zeigen zum ersten Mal die d\u00e4mpfende Wirkung von Sceletium tortuosum auf den Bedrohungskreislauf des menschlichen Gehirns und liefern unterst\u00fctzende Hinweise darauf, dass die duale 5-HT-Wiederaufnahmehemmung und die PDE4-Hemmung dieses Extraktes ein anxiolytisches Potenzial haben k\u00f6nnten, indem sie die subkortikale Bedrohungsreaktion abschw\u00e4chen. Neuropsychopharmakologische Online-Vorabver\u00f6ffentlichung, 21. August 2013; doi:10.1038\/npp.2013.183<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human Amygdala and its connection to the Hypothalamus ...<\/p>","protected":false},"author":2,"featured_media":1730,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-739","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Akute Wirkungen von Sceletium tortuosum (Zembrin) - Zembrin<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zembrin-shop.com\/en\/akute-wirkungen-von-sceletium-tortuosum-zembrin\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Akute Wirkungen von Sceletium tortuosum (Zembrin) - 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